Lactobacillus reuteri extracts promoted wound healing via PI3K/AKT/β-catenin/TGFβ1 pathway.
Nannan HanLu JiaYingying SuJuan DuLijia GuoZhenhua LuoYi LiuPublished in: Stem cell research & therapy (2019)
These data showed that Lactobacillus reuteri extracts could activate the potentials of GMSCs, thus promote wound healing. Our discovery provided the insight of the underlying mechanism activating functions of MSCs and identified Lactobacillus reuteri extracts as a potential therapeutic strategy for accelerating oral wound and potential application in the future dental clinic.
Keyphrases
- wound healing
- pi k akt
- signaling pathway
- cell proliferation
- epithelial mesenchymal transition
- cell cycle arrest
- lactic acid
- small molecule
- mesenchymal stem cells
- primary care
- transforming growth factor
- electronic health record
- current status
- big data
- high throughput
- oral health
- cell death
- umbilical cord
- machine learning
- artificial intelligence
- risk assessment
- bone marrow