Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice.

Kei Ishizuka Kazuyoshi Kon Hyeon-Cheol Lee-Okada Kumiko Arai Akira Uchiyama Shunhei Yamashina Takehiko Yokomizo Kenichi Ikejima

Published in: Journal of gastroenterology and hepatology (2020)

Aging-dependent alterations in lipid metabolism under excessive lipid supply most likely enhance hepatic lipotoxicity, thereby exacerbating metabolic steatohepatitis in elderly.

Keyphrases

high fat diet induced
insulin resistance
fatty acid
middle aged
adipose tissue
liver fibrosis
weight gain
type diabetes
metabolic syndrome
skeletal muscle
community dwelling
physical activity
weight loss