Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer.

Helena A Herrmann Mate RuszDina BaierMichael A JakupecBernhard K KepplerWalter BergerGunda KoellenspergerJuergen Zanghellini

Published in: Cancers (2021)

Here, we elucidate the key importance of normalization steps in the interpretation of metabolomics data, allowing us to uncover drug-specific metabolic reprogramming during acquired metal-drug resistance.

Keyphrases

mass spectrometry
electronic health record
genome wide
big data
gene expression
machine learning
dna methylation
data analysis
artificial intelligence
aqueous solution