Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation.
Deborah CookAdam DeaneFrançois LauzierNicole ZytarukGordon GuyattLois SaundersMiranda HardieDiane Heels-AnsdellWaleed AlhazzaniJohn MarshallJohn MuscedereJohn A MyburghShane EnglishYaseen M ArabiMarlies OstermannSerena KnowlesNaomi E HammondKathleen M ByrneMarianne ChapmanBalasubramanian VenkateshPaul Jeffrey YoungDorrilyn RajbhandariAlexis PooleAbdulrahman Al-FaresGilmar ReisDaniel JohnsonMobeen IqbalRichard HallMaureen MeadeLori HandErick DuanFrance ClarkeJoanna C DionneJennifer L Y TsangBram RochwergTimothy KarachiFrancois LamontagneFrédérick D'AragonCharles St ArnaudBrenda ReeveAnna GeageaDaniel NivenGloria Vazquez-GrandeRyan ZarychanskiDaniel OvakimGordon WoodKaren E A BurnsAlberto GoffiM Elizabeth WilcoxWilliam HendersonDavid ForrestRob FowlerNeill K J AdhikariIan Michael BallTina MeleAlexandra BinnieSebastien TropSangeeta MehtaIngrid MorganOsama LoubaniMeredith VanstoneKirsten FiestEmmanuel CharbonneyYiorgos Alexandros CavayasPatrick ArchambaultOleksa G RewaVincent LauArnold S KristofKosar KhwajaDavid WilliamsonSalmaan KanjiEric SyBrittany DennisSteve ReynoldsFrancois MarquisFrançois LelloucheAdam RahmanPaul HosekJeffrey F BarlettaRobert CirroneMark TutschkaFeng XieLaurent BillotLehana ThabaneSimon R Finfernull nullPublished in: The New England journal of medicine (2024)
Among patients undergoing invasive ventilation, pantoprazole resulted in a significantly lower risk of clinically important upper gastrointestinal bleeding than placebo, with no significant effect on mortality. (Funded by the Canadian Institutes of Health Research and others; REVISE ClinicalTrials.gov number, NCT03374800.).