mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2.

Binsheng WangYu LinYongxian HuWei ShanSenquan LiuYulin XuHao ZhangShuyang CaiXiaohong YuZhen CaiHe Huang

Published in: Stem cell research & therapy (2017)

These results reveal that the mTOR signaling pathway regulates MSC immunobiology, and short-term exposure to rapamycin could be a novel approach to improve the MSC-based therapeutic effect.

Keyphrases

signaling pathway
endothelial cells
cell proliferation
pi k akt
induced pluripotent stem cells
epithelial mesenchymal transition
genome wide
pluripotent stem cells
single cell
induced apoptosis
gene expression
dna methylation