Neural Signatures of Value Comparison in Human Cingulate Cortex during Decisions Requiring an Effort-Reward Trade-off.
Miriam C Klein-FlüggeSteven Wayne KennerleyKarl John FristonSven BestmannPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
The neural processes that govern the trade-off between expected benefits and motor costs remain largely unknown. This is striking because energetic requirements play an integral role in our day-to-day choices and instrumental behavior, and a diminished willingness to exert effort is a characteristic feature of a range of neurological disorders. We use a new behavioral characterization of how humans trade off reward maximization with effort minimization to examine the neural signatures that underpin such choices, using BOLD MRI neuroimaging data. We find the critical neural signature of decision-making, a signal that reflects the comparison of value between choice options, in human cingulate cortex, whereas two distinct brain circuits drive behavior toward reward maximization or effort minimization.
Keyphrases
- functional connectivity
- resting state
- endothelial cells
- decision making
- induced pluripotent stem cells
- magnetic resonance imaging
- pluripotent stem cells
- machine learning
- deep learning
- big data
- white matter
- magnetic resonance
- electronic health record
- gene expression
- dna methylation
- contrast enhanced
- cerebral ischemia
- clinical evaluation