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Identification of VASH1 as a Potential Prognostic Biomarker of Lower-Grade Glioma by Quantitative Proteomics and Experimental Verification.

Yirizhati AiliNuersimanguli MaimaitimingAierpati MaimaitiWen LiuHu QinWenyu JiYusufu MahemutiYongxin WangZengliang Wang
Published in: Journal of oncology (2022)
Our study firstly found that high VASH1 expression was associated with poor prognosis. In addition, We identified the possible mechanism by which VASH1 functioned in LGG. VASH1 inhibits the invasion and migration of tumor cells by affecting microtubule formation and immune infiltration in the tumor microenvironment. May be an important endogenous anti-tumor factor for LGG and provide a potential biomarker for individualized treatment of LGG.
Keyphrases
  • poor prognosis
  • long non coding rna
  • mass spectrometry
  • high resolution
  • cell migration
  • combination therapy
  • human health