Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant.

Sanda AlexandrescuDavid M MeredithHart G LidovRita AlaggioMariangela NovelloKeith L LigonSara O Vargas

Published in: Histopathology (2020)

We conclude that H3K27me3 and TLE1 immunostains, when utilised in combination, can be helpful diagnostic markers for primary intracranial sarcoma, DICER1-mutant.

Keyphrases

poor prognosis
binding protein
wild type
optic nerve
transcription factor
long non coding rna
amino acid
optical coherence tomography