The TOTAL trial dilemma: A survey among professionals on equipoise regarding fetal therapy for severe congenital diaphragmatic hernia.

Simen VergoteDaniel PizzolatoFrancesca RussoKris DierickxJan A Deprest Neeltje M T H Crombag

Published in: Prenatal diagnosis (2020)

Often the views of individual respondents contradicted with their clinical practice. It seems that, for severe CDH, clinicians face personal and practical dilemmas that undermine equipoise. To us, this indicates the tension between the clinical and scientific obligations physicians experience.

Keyphrases

clinical practice
early onset
clinical trial
palliative care
phase iii
drug induced
randomized controlled trial
phase ii
open label