Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort.

Dorrain Yanwen LowSophie Lefèvre-ArbogastRaúl González-DomínguezMireia Urpi-SardaPierre MicheauMelanie PeteraDelphine CentenoStephanie DurandEstelle Pujos-GuillotAniko KorosiPaul J LucassenLudwig AignerCécile Proust-LimaBoris P HejblumCatherine HelmerCristina Andrés-LacuevaSandrine ThuretCécilia SamieriClaudine Manach

Published in: Molecular nutrition & food research (2019)

The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.

Keyphrases

cognitive decline
mass spectrometry
mild cognitive impairment
liquid chromatography
physical activity
weight loss
gas chromatography mass spectrometry
high resolution mass spectrometry
gas chromatography
cancer therapy
simultaneous determination