Porphyromonas gingivalis lipopolysaccharide induces interleukin-6 and c-c motif chemokine ligand 2 expression in cultured hCMEC/D3 human brain microvascular endothelial cells.
Natsu SatoTakeshi MatsumotoShogo KawaguchiKazuhiko SeyaTomoh MatsumiyaJiangli DingTomomi AizawaTadaatsu ImaizumiPublished in: Gerodontology (2021)
IL-6 and CCL2 produced upon P gingivalis LPS stimulation may contribute to the inflammatory reactions in brain endothelial cells and subsequent neurological disorders such as cerebrovascular and Alzheimer's diseases.
Keyphrases
- endothelial cells
- inflammatory response
- high glucose
- poor prognosis
- vascular endothelial growth factor
- toll like receptor
- cerebral ischemia
- oxidative stress
- resting state
- white matter
- cognitive decline
- lps induced
- binding protein
- liver injury
- functional connectivity
- liver fibrosis
- long non coding rna
- multiple sclerosis
- immune response
- blood brain barrier
- brain injury
- mild cognitive impairment
- drug induced