Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions.
Christelle MonvilleOlivier GoureauKarim Ben M'BarekPublished in: Cold Spring Harbor perspectives in medicine (2023)
Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy, and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.
Keyphrases
- pluripotent stem cells
- cell therapy
- optical coherence tomography
- gene therapy
- diabetic retinopathy
- stem cells
- mesenchymal stem cells
- end stage renal disease
- newly diagnosed
- ejection fraction
- single cell
- induced apoptosis
- optic nerve
- healthcare
- peritoneal dialysis
- chronic kidney disease
- prognostic factors
- cell cycle arrest
- cell proliferation
- signaling pathway
- bone marrow
- endoplasmic reticulum stress
- patient reported outcomes
- soft tissue
- induced pluripotent stem cells