Luhong Formula Has a Cardioprotective Effect on Left Ventricular Remodeling in Pressure-Overloaded Rats.
Qian LiuHui-Yan QuHua ZhouJing-Feng RongTian-Shu YangJi-Jie XuXiao-Li YangZhen-Zhen LanPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
LHF can improve left ventricular remodeling in a pressure-overloaded heart failure rat model; this cardiac protective ability may be due to cardiac fibrosis and attenuated apoptosis. Upregulated eNOS expression and downregulated Col1a1, Col3a1, TGF-β1, caspase-3, VEGF, and VEGFR2 expression may play a role in the observed LHF cardioprotective effect.
Keyphrases
- left ventricular
- heart failure
- poor prognosis
- cardiac resynchronization therapy
- hypertrophic cardiomyopathy
- acute myocardial infarction
- left atrial
- aortic stenosis
- mitral valve
- oxidative stress
- cell death
- endothelial cells
- vascular endothelial growth factor
- binding protein
- long non coding rna
- nitric oxide synthase
- cell cycle arrest
- nitric oxide
- signaling pathway