Untargeted metabolomics of human keratinocytes reveals the impact of exposure to 2,6-dichloro-1,4-benzoquinone and 2,6-dichloro-3-hydroxy-1,4-benzoquinone as emerging disinfection by-products.

Dimitra G MeintaniTheodoros G ChatzimitakosAthanasia I KasouniConstantine D Stalikas

Published in: Metabolomics : Official journal of the Metabolomic Society (2022)

Our findings provided insights into the impact of the two DBPs on human keratinocytes. Both chemical factors induced energy production perturbations, oxidative stress, and membrane damage.

Keyphrases

oxidative stress
endothelial cells
mass spectrometry
diabetic rats
high glucose
induced pluripotent stem cells
pluripotent stem cells
drinking water
signaling pathway
high resolution
heat shock protein
solid phase extraction