Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis.

Feifei LinXiaonan WangXin ZhaoMing RenQing-Yu WangJincheng Wang

Published in: Journal of orthopaedic surgery and research (2022)

Abnormally high expression of circ_0001174 may promote the proliferation, migration, and invasion of OS cells through up-regulating MACC1 by sponging miR-186-5p. These results provide insight into therapeutic targets for preventing and treating OS.

Keyphrases

cell proliferation
induced apoptosis
poor prognosis
signaling pathway
cell cycle arrest
pi k akt
endoplasmic reticulum stress
binding protein
long non coding rna