Iminyl Radical-Triggered Intermolecular Distal C(sp3)-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade.

Yu-Rui GuXin-Hua DuanLi ChenZhi-Yong MaPin GaoLi Na Guo

Published in: Organic letters (2019)

An efficient iron-catalyzed intermolecular remote C(sp3)-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.

Keyphrases

electron transfer
visible light
ionic liquid
molecular dynamics
energy transfer
randomized controlled trial
room temperature
minimally invasive
iron deficiency