NOVA2 regulates the properties of liver cancer stem cells and lenvatinib resistance in hepatocellular carcinoma via the Wnt pathway.

Jing-Zhu CaoChao-Qun WangZheng ShiJing-Yun SongFrancisco TustumiTiago Biachi de CastriaJennifer WuChristine PochaDiamantis I TsilimigrasZhi-Hong WangTao TaoJin Lu

Published in: Journal of gastrointestinal oncology (2024)

NOVA2 is involved in the process of liver CSC self-renewal and carcinogenesis. In addition, NOVA2 expression may help identify patients with a higher chance of benefiting from lenvatinib treatment and can be a promising therapeutic target for HCC.

Keyphrases

cancer stem cells
poor prognosis
stem cells
cell proliferation
binding protein