Lipidome atlas of the adult human brain.
Maria OsetrovaAnna TkachevWaltraud MairPatricia Guijarro LarrazOlga I EfimovaIlia KurochkinElena StekolshchikovaNickolay AnikanovJuat Chin FooAmaury Cazenave-GassiotAleksandra MitinaPolina OgurtsovaSong GuoDaria M PotashnikovaAlexander A GulinAlexander A VasinAnastasia SarychevaGleb VladimirovMaria FedorovaYury KostyukevichEvgeny NikolaevMarkus R WenkEkaterina E KhrameevaPhilipp KhaitovichPublished in: Nature communications (2024)
Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain's structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.
Keyphrases
- resting state
- functional connectivity
- fatty acid
- mass spectrometry
- white matter
- high resolution
- risk factors
- machine learning
- multiple sclerosis
- dna methylation
- gene expression
- liquid chromatography
- cancer therapy
- artificial intelligence
- cerebral ischemia
- deep learning
- single cell
- high performance liquid chromatography
- childhood cancer
- high density