Integration of methylation quantitative trait loci (mQTL) on dietary intake on DNA methylation levels: an example of n-3 PUFA and ABCA1 gene.

Ryosuke FujiYoshitaka AndoHiroya YamadaYoshiki TsuboiEiji MunetsunaMirai YamazakiGenki MizunoKeisuke MaedaKoji OhashiHiroaki IshikawaMami WatanabeNahomi ImaedaChiho GotoKenji WakaiShuji HashimotoKoji Suzuki

Published in: European journal of clinical nutrition (2023)

This result suggested that dietary n-3 PUFA intake would be an independent predictor of DNAm levels in ABCA1 gene after adjusting for individual genetic background. Considering mQTL need to broaden into other genes and nutrients for deeper understanding of DNA methylation, which can contribute to personalized nutritional intervention.

Keyphrases

genome wide
dna methylation
copy number
gene expression
randomized controlled trial
high resolution
heavy metals
risk assessment
weight gain
body mass index
transcription factor