HIV-1 and methamphetamine co-treatment in primary human astrocytes: TAARgeting ER/UPR dysfunction.

Jessica M ProulxIn-Woo ParkKathleen Borgmann

Published in: NeuroImmune pharmacology and therapeutics (2024)

Altogether, our findings demonstrate HIV-1/METH-induced ER-mitochondrial dysfunction in astrocytes, whereas TAAR1 may be an upstream regulator for HIV-1/METH-mediated astrocyte dysfunction.

Keyphrases

antiretroviral therapy
hiv positive
hiv testing
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
endothelial cells
oxidative stress
south africa
high glucose
drug induced
pluripotent stem cells