Detecting small cell transformation in patients with advanced EGFR mutant lung adenocarcinoma through epigenomic cfDNA profiling.

Amin H Nassar Catherine B Meador Xintao Qiu Ji-Heui Seo Matthew P Davidsohn Hunter Savignano Gitanjali Lakshminarayanan Heather M McClure John Canniff Brad Fortunato Rong Li Mandeep K Banwait Karl Semaan Marc Eid Henry W Long Yin Pun Hung Navin R Mahadevan David A Barbie Matthew G Oser Zofia Piotrowska Toni K Choueiri Sylvan C Baca Aaron N Hata Matthew L Freedman Jacob E Berchuck

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These data demonstrate the feasibility of detecting small cell transformation in patients with EGFRm LUAD through epigenomic cfDNA profiling of 1 ml of patient plasma.

Keyphrases

single cell
cell therapy
small cell lung cancer
case report
electronic health record
stem cells
tyrosine kinase
machine learning
mesenchymal stem cells
bone marrow