mtDNA dynamics between cleavage-stage embryos and blastocysts.

Neelke De MunckAlberto LiñánIbrahim ElkhatibAşina BayramAna ArnanzCarmen RubioNicolas GarridoBarbara LawrenzHuman M Fatemi

Published in: Journal of assisted reproduction and genetics (2019)

Mitochondrial DNA content of cleavage-stage embryos and blastocysts is unable to predict ploidy status. Subgroup analysis based on ploidy concordance between day 3 and day 5 revealed a significantly lower mtDNA content for true euploid blastocysts. Reproductive ageing does not affect mtDNA content.

Keyphrases

mitochondrial dna
copy number
dna binding
genome wide
dna methylation
clinical trial
randomized controlled trial
single cell
gene expression
transcription factor
open label
data analysis