PPARγ-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines.
Wendy A MillerBeverly R WuertzFrank G OndreyPublished in: The Annals of otology, rhinology, and laryngology (2018)
We conclude the PPARγ activator, pioglitazone, can activate p21, which is associated with decreased proliferation in 2 aerodigestive preneoplastic cell lines. In addition, the p21 gene may be a potential hypothesis-driven biomarker in translational studies of pioglitazone as a chemoprevention agent for aerodigestive cancer.