Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway.
Miao MiaoYongmei DaiCan RuiYuru FanXinyan WangChong FanJuan MuWenwen HouZhiyong DongPing LiGuiju SunTing LuanPublished in: Diabetology & metabolic syndrome (2021)
Our findings indicated improvement of glucose and lipid metabolism by inulin was to activate glucose transport through the translocation of GLUT4 which was mediated by insulin signaling pathway repairment due to decreased expression of RETN and enhanced phosphorylation of IRS and Akt in GDM mice.
Keyphrases
- signaling pathway
- high fat diet induced
- pi k akt
- cell proliferation
- type diabetes
- blood glucose
- poor prognosis
- epithelial mesenchymal transition
- pregnant women
- induced apoptosis
- insulin resistance
- glycemic control
- oxidative stress
- adipose tissue
- binding protein
- skeletal muscle
- metabolic syndrome
- pregnancy outcomes
- protein kinase
- long non coding rna