Substantial discrepancies exist between registered protocol and published manuscript in trials on exercise interventions for chronic low back pain: a metaresearch study.
Silvia BargeriGiacomo BassoIgnazio GeraciGreta CastelliniAlessandro ChiarottoSilvia GianolaRaymond OsteloMarco TestaTiziano InnocentiPublished in: Journal of clinical epidemiology (2024)
We found substantial outcome discrepancies comparing registered protocols and published manuscripts in RCTs assessing exercise interventions for patients with CLBP, with some impacting the statistical significance of the effects. Readers are encouraged to approach RCTs results in this field with caution.