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Identifying distinct neural features between the initial and corrective phases of precise reaching using AutoLFADS.

Wei-Hsien LeeBrianna M KarpowiczChethan PandarinathAdam G Rouse
Published in: bioRxiv : the preprint server for biology (2024)
We analyzed submovement neural population dynamics during precision reaching. Using an auto- encoder-based deep-learning model, AutoLFADS, we examined neural activity on a single-trial basis. Our study shows distinct neural dynamics between initial and corrective submovements. We demonstrate the existence of unique neural features within each submovement class that encode complex combinations of position and reach direction. Our study also highlights the benefit of state-specific decoding strategies, which consider the neural firing rates at the onset of any given submovement, when decoding complex motor tasks such as corrective submovements.
Keyphrases
  • deep learning
  • machine learning
  • randomized controlled trial
  • artificial intelligence
  • phase iii