Allocolchicines─Synthesis with Electro-organic Key Transformations.
Dennis PollokFlorian U RauschSebastian B BeilPeter FranzmannSiegfried R WaldvogelPublished in: Organic letters (2022)
The naturally occurring colchicine and allocolchicines in the meadow saffron are potentially active ingredients for cancer therapy. A concise protocol for the sustainable synthesis of allocolchicines using up to two electro-organic key transformations is demonstrated. This straightforward synthesis of N -acetylcolchinol methyl ether in a five-step protocol was adopted using protecting groups to enable access to N -acetylcolchinol and the phosphate derivative ZD6126.