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Allocolchicines─Synthesis with Electro-organic Key Transformations.

Dennis PollokFlorian U RauschSebastian B BeilPeter FranzmannSiegfried R Waldvogel
Published in: Organic letters (2022)
The naturally occurring colchicine and allocolchicines in the meadow saffron are potentially active ingredients for cancer therapy. A concise protocol for the sustainable synthesis of allocolchicines using up to two electro-organic key transformations is demonstrated. This straightforward synthesis of N -acetylcolchinol methyl ether in a five-step protocol was adopted using protecting groups to enable access to N -acetylcolchinol and the phosphate derivative ZD6126.
Keyphrases
  • cancer therapy
  • randomized controlled trial
  • water soluble
  • drug delivery
  • high speed
  • mass spectrometry