Efficacy and safety of caudal dexmedetomidine in pediatric infra-umbilical surgery: a meta-analysis and trial-sequential analysis of randomized controlled trials.
Ushma Jitendra ShahDerek NguyenNiveditha KaruppiaahJanet MartinHerman SehmbiPublished in: Regional anesthesia and pain medicine (2021)
Our results suggest that the addition of dexmedetomidine to local anesthetic in caudal block significantly improves the duration of analgesia and reduces the analgesic requirements, while maintaining a similar risk-profile compared with local anesthetic alone. Further data on neurological safety are needed.
Keyphrases
- cardiac surgery
- minimally invasive
- coronary artery bypass
- study protocol
- clinical trial
- phase iii
- electronic health record
- big data
- neuropathic pain
- randomized controlled trial
- spinal cord injury
- phase ii
- ultrasound guided
- coronary artery disease
- data analysis
- deep learning
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- chronic pain
- open label
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- acute coronary syndrome
- double blind