DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis.

Miren AltunaAmaya Urdánoz-CasadoJavier Sánchez-Ruiz de GordoaMaría V ZelayaAlberto LabargaJulie M J LepesantMiren RoldánIdoia Blanco-LuquinÁlvaro PerdonesRosa LarumbeIvonne JericóCarmen EchavarriIván Méndez-LópezLuisa Di StefanoMaite Mendioroz

Published in: Clinical epigenetics (2019)

These results suggest that altered DNA methylation in the AD hippocampus occurs at specific regulatory regions crucial for neural differentiation supporting the notion that adult hippocampal neurogenesis may play a role in AD through epigenetic mechanisms.

Keyphrases

dna methylation
cerebral ischemia
subarachnoid hemorrhage
genome wide
blood brain barrier
brain injury
gene expression
endothelial cells
induced pluripotent stem cells
cognitive decline
copy number
neural stem cells
pluripotent stem cells
cognitive impairment