BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription.

Ruonan XuYing FangChunmei HouBing ZhaiZhenyu JiangNing MaLiang WangGencheng HanRenxi Wang

Published in: Cancer cell international (2018)

BC094916 overexpression suppressed Creb1 and Bcl2 transcription to induce cell apoptosis, which suppressed SP 2/0 proliferation and xenograft tumor progression. Thus, BC094916 overexpression may be a potential therapeutic agent for treatment of MM and autoimmune diseases such as SLE.

Keyphrases

transcription factor
cell proliferation
systemic lupus erythematosus
poor prognosis
signaling pathway
disease activity
rheumatoid arthritis
combination therapy
long non coding rna
replacement therapy