In silico investigation of heparanase-correlated genes in breast cancer subtypes.

Carina Mucciolo Melo Henrique Pereira Prado Gabriela Araújo Attie Daniel Lacaz Ruiz Manoel João Batista Castello Girão Maria Aparecida da Silva Pinhal

Published in: Einstein (Sao Paulo, Brazil) (2020)

The signaling pathway analysis using bioinformatics tools gives supporting evidence of possible mechanisms related to breast cancer development. Evasion genes of the immune system co-expressed with heparanase-1, a enzyme related with tumor progression.

Keyphrases

signaling pathway
genome wide
poor prognosis
epithelial mesenchymal transition
bioinformatics analysis
pi k akt
dna methylation
gene expression
oxidative stress
induced apoptosis
genome wide analysis
long non coding rna
breast cancer risk