Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study.
Rodríguez de Dios NFelipe CouñagoMauricio Murcia-MejíaMikel Rico-OsesPatricia Calvo-CrespoPilar SamperCarmen VallejoJavier Luna TiradoItziar TruebaAmalia SotocaCristina CigarralNúria FarréRosa M ManeroXavier DuránJuan-Domingo GispertGonzalo Sánchez-BenavidesTeresa RognoniMargarita TorrenteJaume CapelladesMar JiménezTeresa CabadaMiguel BlancoAna AlonsoJuan Martínez-San MillánJosé EscribanoBeatriz GonzálezJosé Luis López GuerraPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Sparing the hippocampus during PCI better preserves cognitive function in patients with SCLC. No differences were observed with regard to brain failure, OS, and QoL compared with standard PCI.
Keyphrases
- phase iii
- open label
- small cell lung cancer
- clinical trial
- double blind
- phase ii
- placebo controlled
- coronary artery disease
- cerebral ischemia
- percutaneous coronary intervention
- acute myocardial infarction
- acute coronary syndrome
- antiplatelet therapy
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- white matter
- study protocol
- robot assisted
- blood brain barrier
- left ventricular
- randomized controlled trial
- radiation therapy
- brain injury
- prefrontal cortex
- multiple sclerosis
- radiation induced