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The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes.

Joice T GavaliElba D CarrilloMaría C GarcíaJorge A Sánchez
Published in: Cell & bioscience (2020)
Our results suggest that opening mitochondrial potassium ATP channels with diazoxide upregulates the expression of STIM1 and Orai1 by de novo synthesis by a mechanism that involves NFkB, c-Fos, and ROS via MAPK/ERK signaling.
Keyphrases
  • oxidative stress
  • signaling pathway
  • dna damage
  • pi k akt
  • cell death
  • reactive oxygen species
  • poor prognosis
  • cell proliferation
  • young adults