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A transition-metal-free azide-alkyne cycloaddition/hydroamination cascade reaction for the construction of triazole-fused piperazin-2-ones.

Kongxi QiuKaifu WuHaowen MaYunlin AoWei ZhouQian Cai
Published in: Organic & biomolecular chemistry (2024)
A time-dependent, divergent synthesis of highly functionalized [1,2,3]triazolo[1,5- a ]pyrazin-4(5 H )-one (reaction time: 12 h) or 6,7-dihydro-[1,2,3]triazolo[1,5- a ]pyrazin-4(5 H )-one (reaction time: 2 h) scaffolds via a cascade azide-alkyne cycloaddition/hydroamination protocol is reported. The transformation features good functional group compatibility, broad substrate scope, high atom economy and avoidance of the use of transition-metal catalysts.
Keyphrases
  • transition metal
  • electron transfer
  • randomized controlled trial
  • molecular dynamics
  • tissue engineering
  • highly efficient