Insulin receptor substrate-4 is overexpressed in colorectal cancer and promotes retinoblastoma-cyclin-dependent kinase activation.

Patricia Sanmartín-SalinasMaría Del Val Toledo LoboFernando Noguerales-FraguasMiguel Toro LondoñoAntonio Jiménez-RuizLuis Gonzalez Guijarro

Published in: Journal of gastroenterology (2018)

Taken together, our findings suggest that IRS-4 promotes retinoblastoma-cyclin-dependent kinase activation and it may serve as a pharmacological target since its expression is very low in normal tissue, including colonic epithelium.

Keyphrases

cell cycle
type diabetes
poor prognosis
protein kinase
tyrosine kinase
cell cycle arrest
cell proliferation
adipose tissue
cell death
skeletal muscle
insulin resistance
structural basis