CPEB4 - CLOCK crosstalk during temporal lobe epilepsy.

Laura de Diego-GarciaGary P BrennanTheresa AuerAida Menendez-MendezAlberto ParrasAlba Martin-GilMeghma MitraIvana OllàLeticia Villalba-BenitoBeatriz GilMariana AlvesKelvin LauNorman DelantyAlan BeausangJane CryanFrancesca M BrettMichael A FarrellDonncha F O'BrienRaúl MendezGonzalo Carracedo-RodríguezDavid C HenshallJosé J LucasTobias Engel Ayer Botrel

Published in: Epilepsia (2023)

Our results reveal a new positive transcriptional-translational feedback loop (TTFL) involving CPEB4 and CLOCK, which may contribute to the regulation of the sleep-wake cycle during epilepsy.

Keyphrases

temporal lobe epilepsy
transcription factor
gene expression
physical activity
genome wide
sleep quality
single cell
heat shock protein
heat stress