Medicinal Chemistry of Antisense Oligonucleotides for Therapeutic Use in SARS-CoV-2: Design Strategies and Challenges for Targeted Delivery.

Reza Nedaeinia Maryam Ranjbar Mohammad Goli Mahmoud EtebariSaied SafabakhshHasan Bayram Gordon A FernsHelena Moradiyan TehraniRasoul Salehi

Published in: Current medicinal chemistry (2024)

ASOs can be designed to target both coding and non-coding regions of the viral genome to disrupt or completely degrade the genomic RNA and thereby eliminate SARS-CoV-2. They may be very effective in areas, where vaccine distribution is challenging, and they may be helpful for future coronavirus pandemics.

Keyphrases

sars cov
nucleic acid
respiratory syndrome coronavirus
copy number
genome wide
drug discovery