Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke.

Yuguo XiaXiaozheng LingGuowen HuQingwei ZhuJuntao ZhangQing LiBizeng ZhaoYang WangZhi-Feng Deng

Published in: Stem cell research & therapy (2020)

Taken together, our data indicate that iMSC-sEV promote angiogenesis after ischemic stroke, potentially, by inhibiting autophagy, a process that is partially dependent on STAT3 activation.

Keyphrases

endothelial cells
signaling pathway
cell death
endoplasmic reticulum stress
vascular endothelial growth factor
atrial fibrillation
induced pluripotent stem cells
cell proliferation
electronic health record
wound healing
big data
pluripotent stem cells
deep learning
data analysis