Kinetic analysis of endogenous β 2 -adrenoceptor-mediated cAMP GloSensor™ responses in HEK293 cells.

Sean A CullumDmitry B VeprintsevStephen J Hill

Published in: British journal of pharmacology (2022)

Kinetic analysis of real-time signalling data can provide valuable insights into the hemi-equilibria that can occur in low receptor reserve systems with agonist-antagonist interactions, due to incomplete dissociation of antagonist whilst the peak agonist response is developing.

Keyphrases

induced apoptosis
cell cycle arrest
binding protein
electronic health record
big data
endoplasmic reticulum stress
signaling pathway
artificial intelligence
electron transfer
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