DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma.
Lorenzo NeviDi Matteo SabinaCarpino GuidoZizzari Ilaria GraziaSafarikia SamiraAmbrosino ValeriaCostantini DanieleDiletta OveriGiancotti AntonellaMonti MarcoBosco DanielaDe Peppo ValerioOddi AndreaDe Rose Agostino MariaMelandro FabioBragazzi Maria ConsigliaFaccioli JessicaMassironi SaraGrazi Gian LucaPanici Pierluigi BenedettiBerloco Paquale BartomeoGiuliante FeliceCardinale VincenzoInvernizzi PietroCaretti GiuseppinaGaudio EugenioAlvaro DomenicoPublished in: Hepatology (Baltimore, Md.) (2021)
DCLK1 characterizes a specific CSC subpopulation of iCCACD133+ and pCCALGR5+ , and its inhibition exerts anti-neoplastic effects in primary CCA cell cultures. Human DCLK1 serum might represent a serum biomarker for the early CCA diagnosis.