Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

Peter LoudonPieter SiebengaDonal N GormanKatrina GorePinky DuaGuido van AmerongenJustin L HayGeert Jan GroeneveldRichard P Butt

Published in: British journal of clinical pharmacology (2017)

The study demonstrated, for the first time, the translation of nonclinical effects into man in an inflammatory pain analgesic pharmacodynamic endpoint using a pan-Trk inhibitor.

Keyphrases

neuropathic pain
chronic pain
pain management
endothelial cells
oxidative stress
spinal cord
spinal cord injury
induced pluripotent stem cells
anti inflammatory
pluripotent stem cells