Intervention Nonadherence in the TrACER (S1415CD) Study: A Pragmatic Randomized Trial of a Standardized Order Entry for CSF Prescribing.

Dawn L Hershman Aasthaa Bansal William E Barlow Kathryn B Arnold Kate WatabayashiAri Bell-BrownSean D SullivanGary H Lyman Scott D Ramsey

Published in: JCO oncology practice (2023)

In this randomized pragmatic trial aimed at improving PP-CSF prescribing, there was substantial variability in site adherence to the intervention assignment. Although the ability to opt out of the intervention is a feature of pragmatic trials, planning to estimate nonadherence is critical to ensure adequate power.

Keyphrases

randomized controlled trial
study protocol
primary care
phase iii
open label
phase ii
clinical trial
double blind
placebo controlled
emergency department
adverse drug
type diabetes
metabolic syndrome
cerebrospinal fluid
adipose tissue
positron emission tomography