Risk Factors Associated With SARS-CoV-2 Breakthrough Infections in Fully mRNA-Vaccinated Individuals: Retrospective Analysis.

Cong Liu Junghwan Lee Casey Ta Ali Soroush James R Rogers Jae Hyun Kim Karthik Natarajan Jason E Zucker Yehoshua Perl Chunhua Weng

Published in: JMIR public health and surveillance (2022)

Although we found both mRNA vaccines were effective, Moderna/mRNA-1273 had a lower incidence rate of breakthrough infections. Immunocompromised and male individuals were among the highest risk groups experiencing breakthrough infections. Given the rapidly changing nature of the SARS-CoV-2 pandemic, continued monitoring and a generalizable analysis pipeline are warranted to inform quick updates on vaccine effectiveness in real time.

Keyphrases

sars cov
respiratory syndrome coronavirus
binding protein
randomized controlled trial
systematic review
coronavirus disease
risk factors
intensive care unit
extracorporeal membrane oxygenation