Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.

Raúl GonzálezÁngel J De la RosaAlessandro RufiniMaría A Rodríguez-HernándezElena Navarro-VillaránTrinidad MarchalSheila PereiraManuel De la MataMartina Müller-SchillingJuan M Pascasio-AcevedoMaría T Ferrer-RíosMiguel A Gómez-BravoFrancisco J PadilloJordi Muntané

Published in: PloS one (2017)

The reduction of TAp63 and TAp73 isoforms, rather than alteration of ΔN isoform expression, exerted a significant functional repercussion on cell death and proliferation in HBV-expressing HepB cells.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
poor prognosis
hepatitis b virus
signaling pathway
pi k akt