SPARC inhibition accelerates NAFLD-associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism.

Agostina M OnoratoEsteban FioreJuan BayoCecilia CasaliMaría Fernandez-ToméMarcelo RodríguezLuciana DomínguezJosepmaría ArgemiFlorencia HidalgoCristian FavreMariana GarcíaCatalina AtorrasagastiGuillermo D Mazzolini

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

The absence of SPARC is associated with an altered hepatic lipid metabolism, and an accelerated NAFLD-related HCC development.

Keyphrases

fatty acid