Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study.
Kristine F MoseholmHéléne T CronjéManja KochAnnette L FitzpatrickOscar L LopezMarcia C de Oliveira OttoW T LongstrethAndrew N HoofnagleKenneth J MukamalRozenn N LemaitreMajken K JensenPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)
Plasma levels of sphingolipids were associated with cognitive decline and dementia risk.Ceramides and sphingomyelins with palmitic acid were associated with faster annual cognitive decline and increased risk of dementia.The direction of association depended on the covalently bound saturated fatty acid chain length in analysis of cognitive decline.