Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer's disease: an observational clinical study.
Jay AminDelphine BocheZoe CloughJessica TeelingAnthony WilliamsYifang GaoLindsey ChudleyLaurie LauFlorence SmithScott HarrisClive HolmesPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
Peripheral inflammation is altered in DLB compared with AD, with T cell subset analysis supporting a possible shift towards senescence of the adaptive immune system in DLB. Furthermore, there is a proinflammatory signature of serum cytokines in DLB. Identification of this unique peripheral immunophenotype in DLB could guide development of an immune-based biomarker and direct future work exploring potential immune modulation as a novel treatment.