European journal of medicinal chemistry

Keyphrases

Publications

volume 279, 2024

Wanqing Li, Xiaojun Zhang, Jingyin Zhou, Xuan Di, Donglan Huang, Jie Ma, Kaixiang Zhou, Jinming Zhang, Lu Wang, Hualong Fu, Mengchao Cui
Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain. European journal of medicinal chemistry 279 (2024)
Xiaoqing Gong, Shuli Li, Junli Huang, Shuoyan Tan, Qianqian Zhang, Yanan Tian, Qin Li, Lingling Wang, Henry H Y Tong, Xiaojun Yao, Chunxia Chen, Simon Ming-Yuen Lee, Huanxiang Liu
Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation. European journal of medicinal chemistry 279 (2024)
Weijiang Luo, Yiqi Liu, Hui Qin, Zeyan Zhao, Suqi Wang, Weimin He, Shengsong Tang, Junmei Peng
Nitrogen-containing heterocyclic drug products approved by the FDA in 2023: Synthesis and biological activity. European journal of medicinal chemistry 279 (2024)
Héctor Torres-Gómez, François Keiff, Peter Hortschansky, Freddy Bernal, Valerie Kerndl, Florian Meyer, Nina Messerschmidt, Michael Dal Molin, Thomas Krüger, Jan Rybniker, Axel A Brakhage, Florian Kloss
Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones. European journal of medicinal chemistry 279 (2024)
Kyubin Hwang, Juhyeon Bae, Yoo-Lim Jhe, Jungmin Kim, Jae-Ho Cheong, Ha-Soon Choi, Taebo Sim
Targeted degradation of METTL3 against acute myeloid leukemia and gastric cancer. European journal of medicinal chemistry 279 (2024)
Congke Zhao, Yan Wu, Mengqi Li, Wenhua Tan, Yuanbo Hu, Yu Wang, Ruizhe Gao, Liqing Hu, Qianbin Li
Allosteric site identification, virtual screening and discovery of a sulfonamide Hsp110-STAT3 interaction inhibitor for the treatment of hypoxic pulmonary arterial hypertension. European journal of medicinal chemistry 279 (2024)
Manya Aggarwal, Anushree Patra, Ishita Awasthi, Annu George, Simran Gagneja, Varsha Gupta, Neena Capalash, Prince Sharma
Drug repurposing against antibiotic resistant bacterial pathogens. European journal of medicinal chemistry 279 (2024)
Laia Josa-Culleré, Carla Aira Rodríguez, Amadeu Llebaria
Hemithioindigo-based histone deacetylase inhibitors induce a light-dependent anticancer effect. European journal of medicinal chemistry 279 (2024)
Zhen Liu, Yajie Yuan, Ning Wang, Peng Yu, Yuou Teng
Drug combinations of camptothecin derivatives promote the antitumor properties. European journal of medicinal chemistry 279 (2024)
null Ritika, Zi-Yi Liao, Pin-Yu Chen, N Vijayakamasewara Rao, Jacob Mathew, Ram Sharma, Ajmer Singh Grewal, Gurpreet Singh, Sidharth Mehan, Jing Ping Liou, Chun Hsu Pan, Kunal Nepali
Rationally designed febuxostat-based hydroxamic acid and its pH-Responsive nanoformulation elicits anti-tumor activity. European journal of medicinal chemistry 279 (2024)
Ruige Yang, Liping Cui, Ting Xu, Yan Zhong, Songlin Hu, Jifeng Liu, Shangshang Qin, Xiaoliu Wang, Yong Guo
Discovery of membrane-targeting amphiphilic honokiol derivatives containing an oxazolethione moiety to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. European journal of medicinal chemistry 279 (2024)
Zhiqian Lin, Xiangli Ning, Ruizhi Lai, Li Hai, Ruifang Nie, Li Guo, Guobo Li, Zhongzhen Yang, Yong Wu
Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors. European journal of medicinal chemistry 279 (2024)
Yingjie Chang, Xue Li, Yue Zhou, Xinying Yang, Wei Zhao, Hao Fang, Xuben Hou
Simultaneous inhibition of FLT3 and HDAC by novel 6-ethylpyrazine-2-Carboxamide derivatives provides therapeutic advantages in acute myelocytic leukemia. European journal of medicinal chemistry 279 (2024)
Zhangxu He, Weiguang Yang, Feifei Yang, Jingyu Zhang, Liying Ma
Innovative medicinal chemistry strategies for enhancing drug solubility. European journal of medicinal chemistry 279 (2024)
Bushra Mobeen, Muhammad Shah, Hafiz Muzzammel Rehman, Muhammad Saeed Jan, Umer Rashid
Discovery of the selective and nanomolar inhibitor of DPP-4 more potent than sitagliptin by structure-guided rational design. European journal of medicinal chemistry 279 (2024)
Yingjun Zhang, Jianghong Cai, Narayan S Hosmane, Yinghuai Zhu
In silico assessments of the small molecular boron agents to pave the way for artificial intelligence-based boron neutron capture therapy. European journal of medicinal chemistry 279 (2024)
Ravindar Lekkala, Yan Hong Ng, Shevin Rizal Feroz, Nur Aqilah Zahirah Binti Norazmi, Amatul Hamizah Ali, Siti Aishah Hasbullah, Norzila Ismail, Hani Kartini Agustar, Yee Ling Lau, Nurul Izzaty Hassan
Design and synthesis of pyrano[2,3-c]pyrazole-4-aminoquinoline hybrids as effective antimalarial compounds. European journal of medicinal chemistry 279 (2024)
Bingbing Lv, Shuaishuai Xing, Zhiqiang Wang, Ao Zhang, Qinjie Wang, Yaoyao Bian, Yuqiong Pei, Haopeng Sun, Yao Chen
NRF2 inhibitors: Recent progress, future design and therapeutic potential. European journal of medicinal chemistry 279 (2024)
Xi Zhao, Xiaoling Cheng, Zhiying Liu, Weiji Chen, Wenli Hao, Shuangshuang Ma, Jin Zhang, Wei Huang, Dahong Yao
Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo. European journal of medicinal chemistry 279 (2024)
Verdiana Covelli, Michela Buonocore, Manuela Grimaldi, Mario Scrima, Angelo Santoro, Carmen Marino, Veronica De Simone, Lies van Baarle, Francesca Biscu, Maria Carmina Scala, Marina Sala, Gianluca Matteoli, Anna Maria D'Ursi, Manuela Rodriquez
Peptides as modulators of FPPS enzyme: A multifaceted evaluation from the design to the mechanism of action. European journal of medicinal chemistry 279 (2024)
Esraa Z Mohammed, Nehad M El-Dydamony, Enas A Taha, Mostafa N Taha, Ahmed B M Mehany, Hatem A Abdel Aziz, Rehab H Abd El-Aleam
Design, synthesis, and molecular dynamic simulations of some novel benzo[d]thiazoles with anti-virulence activity against Pseudomonas aeruginosa. European journal of medicinal chemistry 279 (2024)
Merve Camci, Halil Şenol, Aytekin Kose, Berin Karaman Mayack, Muhammed Moyasar Alayoubi, Nilgun Karali, Mikail Hakan Gezginci
Bioisosteric replacement of the carboxylic acid group in Hepatitis-C virus NS5B thumb site II inhibitors: phenylalanine derivatives. European journal of medicinal chemistry 279 (2024)
Liang Xue, Ruixue Liu, Lican Zhang, Tingting Qiu, Lu Liu, Ruijuan Yin, Tao Jiang
Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING. European journal of medicinal chemistry 279 (2024)
Jinjin Peng, Bin Ni, Deping Li, Binbin Cheng, Renze Yang
Overview of the PRMT6 modulators in cancer treatment: Current progress and emerged opportunity. European journal of medicinal chemistry 279 (2024)
Dou Dou, Xingsen Zhang, Jie Wang, Gulinuer Wumaier, Yunjin Qiao, Lijuan Xie, Wenzhe Jiang, Wenjie Sha, Wenjie Li, Wenyi Mei, Chen Zhang, Huan He, Caolin Wang, Lingkang Wu, Yanyan Diao, Lili Zhu, Zhenjiang Zhao, Zhuo Chen, Yufang Xu, Shengqing Li, Honglin Li
Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFR L858R/T790M/C797S inhibitors. European journal of medicinal chemistry 279 (2024)
Siyuan Dong, Xi Li, Qi Pan, Kangchun Wang, Ning Liu, Wang Yutao, Yijie Zhang
Nanotechnology-based approaches for antibacterial therapy. European journal of medicinal chemistry 279 (2024)
Lihong Liang, Zhiyong Liu, Jie Chen, Qin Zha, Yihuan Zhou, Jun Li, Yangbo Hu, Xinwen Chen, Tianyu Zhang, Niuniu Zhang
Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase. European journal of medicinal chemistry 279 (2024)
Shanyun Gao, Yingjie Hou, Yanxiao Xu, Jingjing Li, Chaobo Zhang, Shujuan Jiang, Songda Yu, Lei Liu, Wangyang Tu, Bing Yu, Yixiang Zhang, Leping Li
Discovery of orally bioavailable phosphonate prodrugs of potent ENPP1 inhibitors for cancer treatment. European journal of medicinal chemistry 279 (2024)
Angela Lamberti, Marta Serafini, Silvio Aprile, Irene Preet Bhela, Georgia Goutsiou, Emanuela Pessolano, Gregorio Fernandez-Ballester, Antonio Ferrer-Montiel, Rita Maria Concetta Di Martino, Asia Fernandez-Carvajal, Tracey Pirali
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators. European journal of medicinal chemistry 279 (2024)
Chunyan Cai, Dejun Yang, Yi Cao, Zhaolei Peng, Yulin Wang, Jingjing Xi, Chunmei Yan, Xiaofang Li
Anticancer potential of active alkaloids and synthetic analogs derived from marine invertebrates. European journal of medicinal chemistry 279 (2024)
Salvatore Villani, Daniela Imperio, Luigi Panza, Laura Confalonieri, Silvia Fallarini, Silvio Aprile, Erika Del Grosso
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation. European journal of medicinal chemistry 279 (2024)
Yuhan Chen, Meiyu Liang, Wen Li, Zhiming Yang, Xingting Yan, Liuying Wu, Qin Yu, Yubai Chen, Yong Chen, Yan Xu, Wei Song, Zhihong Peng
Water-soluble and predictable-release triptolide prodrugs block bleomycin-induced pulmonary fibrosis in mice. European journal of medicinal chemistry 279 (2024)
Aayishamma I, Gurubasavaraja Swamy Purawarga Matada, Rohit Pal, Abhishek Ghara, Nimmagadda Venkata Satya Sai Aishwarya, Kumaraswamy B, Ketan R Hosamani, Manjushree B V, Haripriya E
Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies. European journal of medicinal chemistry 279 (2024)
Martin Krátký, Neto-Honorius Houngbedji, Jarmila Vinšová
Hydrazinecarboxamides: Comprehensive review of their anticancer, anticonvulsive, anti-inflammatory, enzyme inhibition, antioxidant and other activities. European journal of medicinal chemistry 279 (2024)
Jingxuan Wang, Peng Li, Xue Di, Hongmei Lu, Huamao Wei, Shuai Zhi, David P Fewer, Shan He, Liwei Liu
Phylogenomic analysis uncovers an unexpected capacity for the biosynthesis of secondary metabolites in Pseudoalteromonas. European journal of medicinal chemistry 279 (2024)
Xianpeng Zhang, Hongyu Xu, Ranran Sun, Guihong Xiong, Xugen Shi
An insight into G-quadruplexes: Identification and potential therapeutic targets in livestock viruses. European journal of medicinal chemistry 279 (2024)
Xingyi Zhao, Qiaoguan Hu, Xiaoqian Wang, Chunting Li, Xiao Chen, Dong Zhao, Yue Qiu, Haoyu Xu, Jiaqi Wang, Le Ren, Na Zhang, Shuang Li, Ping Gong, Yunlei Hou
Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease. European journal of medicinal chemistry 279 (2024)
Tianwen Luo, Yanting Zhou, Rui Wu, Honghai Yin, Weiyao Xie, Hui Meng, Chenyao Zhao, Yanli Wang, Yongle Wang, Leyi Kang, Xiaoai Wu, Changning Wang, Ping Bai
Design, synthesis, and preclinical evaluation of 11 C/ 18 F-labeled inhibitors for RIPK1 PET imaging. European journal of medicinal chemistry 279 (2024)
Xiuzhen Wei, Xi Zhang, Yan Peng, Junbo Wu, Hanxuan Mo, Zhigang An, Xinyu Deng, Ying Peng, Linyi Liu, Weifan Jiang, Jinjin Chen, Zecheng Hu, Zhen Wang, Linsheng Zhuo
Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma. European journal of medicinal chemistry 279 (2024)
Takeshi Yokoyama, Kotono Hisatomi, Saki Oshima, Ichiro Tanaka, Takuya Okada, Naoki Toyooka
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor. European journal of medicinal chemistry 279 (2024)
Xijun Zhong, Jizhou Wu, Na Du, Sheng Zhou, Chao Ma, Tiezheng Xue, Meng Wei, Jiaqi Gong, Bin Wang, Mingliang Liu, Apeng Wang, Kai Lv, Yu Lu
Design, synthesis and antimycobacterial activity of novel benzothiazinones with improved water solubility. European journal of medicinal chemistry 279 (2024)
Zheng-Rui Xiang, Shi-Rui Fan, Juan Ren, Ting Ruan, Yuan Chen, Yun-Wu Zhang, Yi-Ting Wang, Ze-Zhou Yu, Chao-Fan Wang, Xiao-Long Sun, Xiao-Jiang Hao, Duo-Zhi Chen
Utilizing artificial intelligence for precision exploration of N protein targeting phenanthridine sars-cov-2 inhibitors: A novel approach. European journal of medicinal chemistry 279 (2024)
Jingjing Peng, Xiaoyu Ding, Pei-Yu Shih, Qingyuan Meng, Xiao Ding, Man Zhang, Alex Aliper, Feng Ren, Hongfu Lu, Alex Zhavoronkov
Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European journal of medicinal chemistry 279 (2024)
Xiashi Lv, Peifeng Li, Zhuo Chen, Siting Huang, Shuang Zhang, Bei Ji, Jingjing Liu, Tonghong Du, Tingting Zhang, Xijing Chen, Lei Qiang, Yuan He, Yisheng Lai
Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors. European journal of medicinal chemistry 279 (2024)
Theodoros Rampias, Thomas Antoniou, Annelies Stevaert, Lara Kravariti, Benjamin Van Loy, Julie Vandeput, Jacopo Sgrignani, Natalia Filippidou, Patrizia Locatelli, Martina Samiotaki, Eleftherios Paraskevas Tzakos, Andrea Cavalli, Lieve Naesens, Diamantis C Sideris, Andreas G Tzakos
Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease. European journal of medicinal chemistry 279 (2024)
Narayanaperumal Pravin, Krzysztof Jóźwiak
PROTAC unleashed: Unveiling the synthetic approaches and potential therapeutic applications. European journal of medicinal chemistry 279 (2024)
Haoxuan Zhou, Mingxing Hu, Hui Jie, Yujue Li, Kexin Tang, LiLi Pan, Chengyali Liu, Zi Liu, Wei Chen, Yuanwei Chen, Yi Luo, Youling Gong, Yongmei Xie
Discovery of orally bioavailable ALK PROTACs based ceritinib against ALK positive cancers. European journal of medicinal chemistry 279 (2024)
Weiping Lyu, Haoming Qin, Qi Li, Dehua Lu, Cheng Shi, Kangchen Zhao, Shengran Zhang, Ruohan Yu, Huiying Zhang, Xiaonan Zhou, Sitian Xia, Liangren Zhang, Xiaoqian Wang, Xiaowei Chi, Zhenming Liu
Novel mechanistic insights - A brand new Era for anti-HBV drugs. European journal of medicinal chemistry 279 (2024)
Jina Kim, Tara Man Kadayat, Jae-Eon Lee, Sugyeong Kwon, Kyungjin Jung, Ji Sun Hwang, Oh-Bin Kwon, Ye Jin Kim, Yeon-Kyung Choi, Keun-Gyu Park, Hayoung Hwang, Sung Jin Cho, Taeho Lee, Yong Hyun Jeon, Jungwook Chin
Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders. European journal of medicinal chemistry 279 (2024)

volume 278, 2024

Katherine T Andrews, Gillian M Fisher, Meaghan Firmin, Andris J Liepa, Tony Wilson, James Gardiner, Yacine Mohri, Emmanuel Debele, Anjana Rai, Andrew K Davey, Antoine Masurier, Alix Delion, Alexandros A Mouratidis, Oliver E Hutt, Craig M Forsyth, Jeremy N Burrows, John H Ryan, Andrew G Riches, Tina S Skinner-Adams
Discovery of 1,3,4-oxadiazoles with slow-action activity against Plasmodium falciparum malaria parasites. European journal of medicinal chemistry 278 (2024)