Journal of enzyme inhibition and medicinal chemistry

Keyphrases

Publications

volume 39, number 1, 2024

Elisa Rojas-Prats, Loreto Martínez-González, Carmen Gil, David Ramírez, Ana Martinez
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mateusz Olszewski, Natalia Maciejewska, Anoop Kallingal, Agnieszka Chylewska, Aleksandra M Dąbrowska, Małgorzata Biedulska, Mariusz Makowski, José M Padrón, Maciej Bagiński
Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu
Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yinglin Liao, Peng Cao, Lianxiang Luo
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Marwa E Abdelaziz, Mostafa M M El-Miligy, Salwa M Fahmy, Marwa M Abu-Serie, Aly A Hazzaa, Mona A Mahran
Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yinglin Liao, Peng Cao, Lianxiang Luo
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu
Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Roaa S Bibars, Qosay A Al-Balas
Computational fragment-based drug design of potential Glo-I inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Marwa E Abdelaziz, Mostafa M M El-Miligy, Salwa M Fahmy, Marwa M Abu-Serie, Aly A Hazzaa, Mona A Mahran
Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mengfan Zhu, Jinfeng Qu, Qi Deng
Identification of potential inhibitors against Staphylococcus aureus shikimate dehydrogenase through virtual screening and susceptibility test. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yinglin Liao, Peng Cao, Lianxiang Luo
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Design, synthesis, and bioevaluation of 1 h -pyrrolo[3,2- c ]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Elisa Rojas-Prats, Loreto Martínez-González, Carmen Gil, David Ramírez, Ana Martinez
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mohamed A Mahmoud, Anber F Mohammed, Ola I A Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G M Youssif
Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mostafa M M El-Miligy, Ahmed K Al-Kubeisi, Rasha A Nassra, Saad R El-Zemity, Aly A Hazzaa
Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mostafa M M El-Miligy, Ahmed K Al-Kubeisi, Rasha A Nassra, Saad R El-Zemity, Aly A Hazzaa
Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu
Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mohamed A Mahmoud, Anber F Mohammed, Ola I A Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G M Youssif
Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yong-Xin Luo, Xu Gong, Zhi-Cheng Su, Jin-Feng Mo, Dong-Li Li, Ri-Hui Wu, Jing-Wei Jin, Ming Lang, Jin-Ping Wang, Xue-Tao Xu, Li-She Gan
Isolation, structure modification, and anti-rheumatoid arthritis activity of isopimarane-type diterpenoids from Orthosiphon aristatus . Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mengfan Zhu, Jinfeng Qu, Qi Deng
Identification of potential inhibitors against Staphylococcus aureus shikimate dehydrogenase through virtual screening and susceptibility test. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yong-Xin Luo, Xu Gong, Zhi-Cheng Su, Jin-Feng Mo, Dong-Li Li, Ri-Hui Wu, Jing-Wei Jin, Ming Lang, Jin-Ping Wang, Xue-Tao Xu, Li-She Gan
Isolation, structure modification, and anti-rheumatoid arthritis activity of isopimarane-type diterpenoids from Orthosiphon aristatus . Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yong-Xin Luo, Xu Gong, Zhi-Cheng Su, Jin-Feng Mo, Dong-Li Li, Ri-Hui Wu, Jing-Wei Jin, Ming Lang, Jin-Ping Wang, Xue-Tao Xu, Li-She Gan
Isolation, structure modification, and anti-rheumatoid arthritis activity of isopimarane-type diterpenoids from Orthosiphon aristatus . Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Design, synthesis, and bioevaluation of 1 h -pyrrolo[3,2- c ]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Design, synthesis, and bioevaluation of 1 h -pyrrolo[3,2- c ]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mateusz Olszewski, Natalia Maciejewska, Anoop Kallingal, Agnieszka Chylewska, Aleksandra M Dąbrowska, Małgorzata Biedulska, Mariusz Makowski, José M Padrón, Maciej Bagiński
Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mateusz Olszewski, Natalia Maciejewska, Anoop Kallingal, Agnieszka Chylewska, Aleksandra M Dąbrowska, Małgorzata Biedulska, Mariusz Makowski, José M Padrón, Maciej Bagiński
Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yinglin Liao, Peng Cao, Lianxiang Luo
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Elisa Rojas-Prats, Loreto Martínez-González, Carmen Gil, David Ramírez, Ana Martinez
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Elisa Rojas-Prats, Loreto Martínez-González, Carmen Gil, David Ramírez, Ana Martinez
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mohamed A Mahmoud, Anber F Mohammed, Ola I A Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G M Youssif
Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mostafa M M El-Miligy, Ahmed K Al-Kubeisi, Rasha A Nassra, Saad R El-Zemity, Aly A Hazzaa
Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Yinglin Liao, Peng Cao, Lianxiang Luo
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mostafa M M El-Miligy, Ahmed K Al-Kubeisi, Rasha A Nassra, Saad R El-Zemity, Aly A Hazzaa
Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mohamed A Mahmoud, Anber F Mohammed, Ola I A Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G M Youssif
Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Roaa S Bibars, Qosay A Al-Balas
Computational fragment-based drug design of potential Glo-I inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu
Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Roaa S Bibars, Qosay A Al-Balas
Computational fragment-based drug design of potential Glo-I inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Naglaa M Ahmed, Mosaad S Mohamed, Samir M Awad, Rania H Abd El-Hameed, Neama A Abd El-Tawab, Mohamed S Gaballah, Ahmed M Said
Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mengfan Zhu, Jinfeng Qu, Qi Deng
Identification of potential inhibitors against Staphylococcus aureus shikimate dehydrogenase through virtual screening and susceptibility test. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Marwa E Abdelaziz, Mostafa M M El-Miligy, Salwa M Fahmy, Marwa M Abu-Serie, Aly A Hazzaa, Mona A Mahran
Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Naglaa M Ahmed, Mosaad S Mohamed, Samir M Awad, Rania H Abd El-Hameed, Neama A Abd El-Tawab, Mohamed S Gaballah, Ahmed M Said
Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mohamed Elagawany, Lina M A Abdel Ghany, Tarek S Ibrahim, Abdulrhman S Alharbi, Mohamed S Abdel-Aziz, Eman M El-Labbad, Noha Ryad
Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Roaa S Bibars, Qosay A Al-Balas
Computational fragment-based drug design of potential Glo-I inhibitors. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Mateusz Olszewski, Natalia Maciejewska, Anoop Kallingal, Agnieszka Chylewska, Aleksandra M Dąbrowska, Małgorzata Biedulska, Mariusz Makowski, José M Padrón, Maciej Bagiński
Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Marwa E Abdelaziz, Mostafa M M El-Miligy, Salwa M Fahmy, Marwa M Abu-Serie, Aly A Hazzaa, Mona A Mahran
Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Design, synthesis, and bioevaluation of 1 h -pyrrolo[3,2- c ]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)