Xenobiotica; the fate of foreign compounds in biological systems

Keyphrases

Publications

volume 54, number 3, 2024

N F Ebaid, K S Abdelkawy, M A Shehata, H F Salem, G Magdy, R R S Hussein, F Elbarbry
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Li Shao, Jiajia Mo, Qinlong Xu, Guangwei He, Chunyu Xing, Zhaoxing Chu
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Alexander Treiber, Swen Seeland, Belal Haschimi, Aude Weigel, Jodi T Williams, Jerome Gabillet
The metabolism of the orexin-1 selective receptor antagonist nivasorexant. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Alexander Treiber, Swen Seeland, Belal Haschimi, Aude Weigel, Jodi T Williams, Jerome Gabillet
The metabolism of the orexin-1 selective receptor antagonist nivasorexant. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
N F Ebaid, K S Abdelkawy, M A Shehata, H F Salem, G Magdy, R R S Hussein, F Elbarbry
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Li Shao, Jiajia Mo, Qinlong Xu, Guangwei He, Chunyu Xing, Zhaoxing Chu
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Alexander Treiber, Swen Seeland, Belal Haschimi, Aude Weigel, Jodi T Williams, Jerome Gabillet
The metabolism of the orexin-1 selective receptor antagonist nivasorexant. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami, Miki Nakajima
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Rongrong Wang, Tianlin Wang, Xueliang Han, Mengli Chen, Shu Li
Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)
Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami, Miki Nakajima
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model. Xenobiotica; the fate of foreign compounds in biological systems 54 (3) (2024)

volume 54, number 4, 2024

Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Faleh Alqahtani
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Jiayu Li, Shuofeng Zhang, Rui Chen
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson's drug FLZ after multi-dose in cynomolgus monkeys. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Yuexia Li, Liheng Liu
Drug-drug interaction between danshensu and irbesartan and its potential mechanism. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Jiayu Li, Shuofeng Zhang, Rui Chen
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson's drug FLZ after multi-dose in cynomolgus monkeys. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Faleh Alqahtani
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Congrong Wang, Naixiang Zhou, Mingcui Li, Haixia Chen
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Yuexia Li, Liheng Liu
Drug-drug interaction between danshensu and irbesartan and its potential mechanism. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Congrong Wang, Naixiang Zhou, Mingcui Li, Haixia Chen
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Alexander Treiber, Swen Seeland, Jérôme Segrestaa, Cyrille Lescop, Martin H Bolli
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Alexander Treiber, Swen Seeland, Jérôme Segrestaa, Cyrille Lescop, Martin H Bolli
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)
Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Faleh Alqahtani
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations. Xenobiotica; the fate of foreign compounds in biological systems 54 (4) (2024)

volume 54, number 5, 2024

Markus Walles, A Pähler, E M Isin, Marie M Ahlqvist
Meeting report of the 4th European biotransformation workshop. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Itsuma Nagao, Meg Nakazawa, Takashi Goyama, Michael H Court, Yoko M Ambrosini
Assessment of cytochrome P450 induction in canine intestinal organoid models. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Hiroko Makihara, Mika Maezawa, Kazusa Kaiga, Toshihiko Satake, Mayu Muto, Yui Tsunoda, Tsutomu Shimada, Tomoko Akase
mRNA expression levels of cytochrome P450 CYP1A2 , CYP3A4 , and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Itsuma Nagao, Meg Nakazawa, Takashi Goyama, Michael H Court, Yoko M Ambrosini
Assessment of cytochrome P450 induction in canine intestinal organoid models. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Danqing Wu, Rui Luo, Yangnan Chen, Zhiyun Zheng, Shuangying Gui, Ning He
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Ziyang Xu, Lianzhan Sun, Chang Yin, Handa Wu, Xue Wang, Yunyun Yang, Zhuo Wang
Developmental stage and infection status may affect drug distribution in the prostate of rats. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Itsuma Nagao, Meg Nakazawa, Takashi Goyama, Michael H Court, Yoko M Ambrosini
Assessment of cytochrome P450 induction in canine intestinal organoid models. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Markus Walles, A Pähler, E M Isin, Marie M Ahlqvist
Meeting report of the 4th European biotransformation workshop. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)
Markus Walles, A Pähler, E M Isin, Marie M Ahlqvist
Meeting report of the 4th European biotransformation workshop. Xenobiotica; the fate of foreign compounds in biological systems 54 (5) (2024)

volume 54, number 6, 2024

Justyna Popiół, Agnieszka Gunia-Krzyżak, Karolina Słoczyńska, Kamil Piska, Natalia Kocot, Dorota Żelaszczyk, Anna Krupa, Katarzyna Wójcik-Pszczoła, Henryk Marona, Elżbieta Pękala
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) - the novel potential UV filter designed by means of a double chromophore strategy. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Riya Nilkant, Chintha Kathiresan, Namrata Kumar, Steve Caritis, Imam H Shaik, Raman Venkataramanan
Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Riya Nilkant, Chintha Kathiresan, Namrata Kumar, Steve Caritis, Imam H Shaik, Raman Venkataramanan
Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Hai Nguyen Duc, Thuy Linh Hoang, Giang Huong Vu
An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Itsuma Nagao, Meg Nakazawa, Yurika Tachibana, Minae Kawasaki, Yoko M Ambrosini
Assessment of P-glycoprotein function using canine intestinal organoid-derived epithelial interfaces. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
S C Mitchell, R H Waring
Academic foreign compound metabolism - ' quo vadis '? Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Hai Nguyen Duc, Thuy Linh Hoang, Giang Huong Vu
An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Paula Ichinose, María Victoria Miró, Paula Viviani, Juan Manuel Herrera, Adrian Luis Lifschitz, Guillermo L Virkel
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Itsuma Nagao, Meg Nakazawa, Yurika Tachibana, Minae Kawasaki, Yoko M Ambrosini
Assessment of P-glycoprotein function using canine intestinal organoid-derived epithelial interfaces. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Riya Nilkant, Chintha Kathiresan, Namrata Kumar, Steve Caritis, Imam H Shaik, Raman Venkataramanan
Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Fei Liu, Aibin Zheng, Min Li, Yang Chen, Xiaodong Liu
Study on pharmacokinetics and tissue distribution of deoxypodophyllotoxin and its metabolites in tumour-bearing mice. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)
Anna Kerins, Phil Butler, Rob Riley, Marta Koszyczarek, Caroline Smith, Faye Cruickshank, Vamsi Madgula, Nilkanth Naik, Matthew R Redinbo, Ian D Wilson
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1. Xenobiotica; the fate of foreign compounds in biological systems 54 (6) (2024)

volume 54, number 7, 2024

Erik Gawehn, Nigel Greene, Filip Miljković, Olga Obrezanova, Vigneshwari Subramanian, Maria-Anna Trapotsi, Susanne Winiwarter
Perspectives on the use of machine learning for ADME prediction at AstraZeneca. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Maria Luisa Sardu, Italo Poggesi
Pharmacokinetics of intranasal drugs, still a missed opportunity? Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Jeffrey L Woodhead, Yeshi Gebremichael, Joyce Macwan, Irfan A Qureshi, Richard Bertz, Victoria Wirtz, Brett A Howell
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Alan G E Wilson
Xenobiotica Special Edition Preface. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Jeffrey L Woodhead, Yeshi Gebremichael, Joyce Macwan, Irfan A Qureshi, Richard Bertz, Victoria Wirtz, Brett A Howell
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Alan G E Wilson
Xenobiotica Special Edition Preface. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Ningyuan Zhang, Yu Li, Wenbin Cui, Xiangqing Yu, Ying Huang
Application of quantitative pharmacology analysis to support early clinical development of oncology drugs: dose selection. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)
Shunnosuke Kaito, Jun-Ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica; the fate of foreign compounds in biological systems 54 (7) (2024)